Journal of Molecular Cell Biology | Oxford Academic

Time 2020-12-06 19:04:05

Web Name: Journal of Molecular Cell Biology | Oxford Academic

WebSite: http://jmcb.oxfordjournals.org

ID:125720

Keywords:

Molecular,of,Journal,

Description:

We use cookies to enhance your experience on our website.By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Find out more Organoids are self-organizingin vitrothree-dimensional (3D) tissue cultures containing multiple types of cells. Compared to traditional two-dimensional (2D) cell culture systems, 3D organoids better replicate the architecture, complexity, and physiology of an organ.In addition, 3D organoids are easier to scale up and more cost-efficient when compared to animal models. Featured articles Mps1 dimerization and multisite interactions with Ndc80 complex enable responsive spindle assembly checkpoint signaling Error-free mitosis depends on accurate chromosome attachment to spindle microtubules, which is monitored by the spindle assembly checkpoint (SAC) signaling. As an upstream factor of SAC, the precise and dynamic kinetochore localization of Mps1 kinase is critical for initiating and silencing SAC signaling. However, the underlying molecular mechanism remains elusive. Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype Restoration of kidney tubular epithelium following sublethal injury sequentially involves partial epithelial–mesenchymal transition (pEMT), proliferation, and further redifferentiation into specialized tubule epithelial cells (TECs). Because the immunosuppressant cyclosporine-A produces pEMT in TECs and inhibits the peptidyl-prolyl isomerase (PPIase) activity of cyclophilin (Cyp) proteins, we hypothesized that cyclophilins could regulate TEC phenotype. Dependence of sperm structural and functional integrity on testicular calcineurin isoform PPP3R2 expression After leaving the testis, mammalian sperm undergo a sequential maturation process in the epididymis followed by capacitation during their movement through the female reproductive tract. These phenotypic changes are associated with modification of protein phosphorylation and membrane remodeling, which is requisite for sperm to acquire forward motility and induce fertilization. However, the molecular mechanisms underlying sperm maturation and capacitation are still not fully understood. Maternal miR-202-5p is required for zebrafish primordial germ cell migration by protecting small GTPase Cdc42 In many lower animals, germ cell formation, migration, and maintenance depend on maternally provided determinants in germ plasm. In zebrafish, these processes have been extensively studied in terms of RNA-binding proteins and other coding genes. The role of small non-coding RNAs in the regulation of primordial germ cell (PGC) development remains largely unknown and poorly investigated, even though growing interests for the importance of miRNAs involved in a wide variety of biological processes. Latest articles JMCB is now fully Open Access and all articles are published under a CC BY or CC BY-NC licence. The latest articles can be found in theAdvance Articles. Editor's Choice Collection Explore articles highlighted by peer experts and editors. Fast Green Track The 'Fast Green Track' option is available for previously reviewed manuscripts or manuscripts in fierce competition.Discovermore details Submit Accepting high quality clinical and scientific papers relating to all aspects of Molecular Cell Biology.Submit Related Titles Carcinogenesis DNA Research Molecular Human Reproduction Human Molecular Genetics International Immunology Food Quality and Safety Nucleic Acids Research Oxford Open Immunology Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide This PDF is available to Subscribers Only View Article Abstract & Purchase Options For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Close

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Publishes authoritative reviews and high quality articles in all areas of molecular and cell biology, especially in inter-disciplinary studies at the cross-sect

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