News | TBI-IMPACT.org

Time 2020-12-18 18:03:58

Web Name: News | TBI-IMPACT.org

WebSite: http://www.tbi-impact.org

ID:138388

Keywords:

TBI,News,org,

Description:

Traumatic Brain Injury (TBI) may afflict us all, but young adult males are particularly at risk. IMPACT is an international multidisciplinary effort to advance clinical research programmes in search of better treatment. Nearly 10 years of work has resulted in the development of a prognostic calculator for establishing prognosis in individual patients, proposals for standardization of data collection in TBI studies (common data elements) and recommendations for improving the design and analysis of TBI studies. It is hoped that these recommendations will substantially increase possibilities for proving efficacy of new treatments. We greatly welcome any feedback you may have Background Traumatic Brain Injury (TBI) is a dynamic and heterogeneous disease in which many mechanisms and pathways can lead to secondary damage. Many different kinds of therapy and neuroprotective agents with high potential for efficacy have been developed. Unfortunately in trials none of these have shown convincing evidence of benefit in the clinical situation with sufficient generalizibility. Some of these therapies may have been truly ineffective but the risk exists that some therapies may have been wrongly discarded due to the use of insensitive methodology in clinical trials. The TBI population poses several complicated methodological challenges, related to the heterogeneity of the population, outcome-assessment and design issues. IMPACT is focused on tackling these head-on with the aim of providing recommendations for more powerful trials in the future. Collaborating IMPACT institutes The IMPACT Project is focused on advancing knowledge of prognosis, trial-design and treatment in TBI. IMPACT has developed and validated prognostic models for classification and characterization of TBI series participated in the development of standardization of data collection in TBI studies (common data elements). provided evidence based recommendations for improving sensitivity and efficiency of trials in TBI IMPACT will continue its research efforts towards provision of further evidence in support of efforts to improve treatment. Advise and assist in the development of clinical research programmes, investigating new treatments for TBI which could lead to better patients outcomes. Most important IMPACT recommen-dations for TBI trials Calculate the prediction models for 6 month outcome after TBI with the help of our online prognostic calculator. Common Data Elements summarize proposals for selection and coding of variables for TBI studies. Currently, this is a draft/beta version. Feedback or comments are very welcome and will be highly appreciated.

TAGS:TBI News org 

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