Home | Cancer Discovery

Time 2020-09-19 07:02:54

Web Name: Home | Cancer Discovery

WebSite: http://cancerdiscovery.aacrjournals.org

ID:51886

Keywords:

Home,Cancer,Discovery,

Description:

The AACR remains fully committed to supporting publishing operations throughout this challenging time, while still remaining flexible and supportive of the author, reviewer, and editor communities that we serve. If you have any questions or concerns, please reach out to a member of the AACR publishing staff. Please visit the COVID-19 Cancer Resource Center where COVID-related content is freely available. Research Brief Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2 Gretchen M. Alicea, Vito W. Rebecca, Aaron R. Goldman, Mitchell E. Fane, Stephen M. Douglass, Reeti Behera, Marie R. Webster, Curtis H. Kugel III, Brett L. Ecker, M. Cecilia Caino, Andrew V. Kossenkov, Hsin-Yao Tang, Dennie T. Frederick, Keith T. Flaherty, Xiaowei Xu, Qin Liu, Dmitry I. Gabrilovich, Meenhard Herlyn, Ian A. Blair, Zachary T. Schug, David W. Speicher and Ashani T. Weeraratna Cancer Discov September 1 2020 10 (9) 1282-1295; DOI:10.1158/2159-8290.CD-20-0329 Aged dermal fibroblasts secreted altered levels of several lipids, which entered melanoma cells via the fatty acid transporter FATP2, the inhibition of which synergized with targeted therapy in aged mice. Research Articles | AuthorChoice Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer Yann Kieffer, Hocine R. Hocine, Géraldine Gentric, Floriane Pelon, Charles Bernard, Brigitte Bourachot, Sonia Lameiras, Luca Albergante, Claire Bonneau, Alice Guyard, Karin Tarte, Andrei Zinovyev, Sylvain Baulande, Gerard Zalcman, Anne Vincent-Salomon and Fatima Mechta-Grigoriou Cancer Discov September 1 2020 10 (9) 1330-1351; DOI:10.1158/2159-8290.CD-19-1384 An immunosuppressive subtype of cancer-associated fibroblast was heterogeneous, with only certain subsets modulating immune-cell infiltration in the tumor microenvironment and immunotherapy response. Research Articles Epigenetic Switch–Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer Geneviève Deblois, Seyed Ali Madani Tonekaboni, Giacomo Grillo, Constanza Martinez, Yunchi Ingrid Kao, Felicia Tai, Ilias Ettayebi, Anne-Marie Fortier, Paul Savage, Alexandra N. Fedor, Xiaojing Liu, Paul Guilhamon, Evelyne Lima-Fernandes, Alex Murison, Hellen Kuasne, Wail Ba-alawi, David W. Cescon, Cheryl H. Arrowsmith, Daniel D. De Carvalho, Benjamin Haibe-Kains, Jason W. Locasale, Morag Park and Mathieu Lupien Cancer Discov September 1 2020 10 (9) 1312-1329; DOI:10.1158/2159-8290.CD-19-1493 Taxane-resistant triple-negative breast cancer cells had altered methionine metabolism, leading to epigenetic changes at transposable elements and creating a therapeutic vulnerability to EZH2 inhibitors. Review Toward a New Molecular Taxonomy of Diffuse Large B-cell Lymphoma Daisuke Ennishi, Eric D. Hsi, Christian Steidl and David W. Scott Cancer Discov September 1 2020 10 (9) 1267-1281; DOI:10.1158/2159-8290.CD-20-0174 Review Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer Michele Carbone, J. William Harbour, James Brugarolas, Angela Bononi, Ian Pagano, Anwesha Dey, Thomas Krausz, Harvey I. Pass, Haining Yang and Giovanni Gaudino Cancer Discov August 1 2020 10 (8) 1103-1120; DOI:10.1158/2159-8290.CD-19-1220 Mini Review Targeting MET Dysregulation in Cancer Gonzalo Recondo, Jianwei Che, Pasi A. Jänne and Mark M. Awad Cancer Discov July 1 2020 10 (7) 922-934; DOI:10.1158/2159-8290.CD-19-1446 Mini Review Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment Erin Helms, M. Kathrina Onate and Mara H. Sherman Cancer Discov May 1 2020 10 (5) 648-656; DOI:10.1158/2159-8290.CD-19-1353 Free Article | Q A: Solange Peters on COVID-19, Cancer Intersection; Immunotherapy Biomarkers Says virus likely to cause a substantial number of deaths in patients with cancer who aren t infected; discusses personalizing lung cancer treatment. Exosome Profiling Pinpoints Cancer Type Tumor vesicles carry characteristic proteins that may support disease diagnosis. Precision Medicine Stumbles in Umbrella Trial Many targeted therapies fail to produce responses in lung cancer.

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