Biomedical engineers and ophthalmologists from Duke University, USA, have designed and demonstrated a hands-free automated version of a standard desktop optical coherence tomography (OCT) scanner. The research team believes that the setup may expand the valuable technologys reach to primary care offices and emergency departments. In proof-of-concept demonstrations, the scanner, which is attached to a robotic arm, produced images of the cornea and retina that are comparable to standard tabletop systemsin less than 10 seconds (Nat. Biomed. Eng., doi: 10.1038/s41551-021-00753-6 ).

Nipro Medical Corporation is proud to announce a commercial partnership in the United States with Gentuity LLC . Gentuity, an imaging technology firm founded in Massachusetts in 2015, is dedicated to developing next-generation intravascular devices that capitalize on todays best-in-class technologies. With a proprietary platform fully incorporating the companys AI tools to enhance ease of use and procedural success, Gentuity is transforming the world of intravascular imaging. Together with Gentuity, Nipro is excited to continue advancing patient care, improving outcomes, and delivering more value to healthcare providers. EXPERIENCE THE NEXT GENERATION OF OCT Nipro is excited to now offer ...

The Bio-Optics Optical Engineering Lab at the Nicolaus Copernicus University invites applications for the PhD student position in a project entitled Lenticular and vitreal light scattering and refraction for tomorrow's eye diagnostics financed by the Foundation for Polish Science (Programme TEAM) from the Smart Growth Operational Programme funds (PO IR) in 2014-2020. The project aims at the development and clinical validation of novel imaging-based tools to extract spatially resolved information on the light scattering and refraction in the ocular structures and media. The project addresses fundamental challenges regarding non-invasive measurements of the optical properties of ocular structures that form ...

We present a completely label-free three-dimensional (3D) optical coherence tomography (OCT)-based tissue dynamics imaging method for visualization and quantification of the metabolic and necrotic activities of tumor spheroid. Our method is based on a custom 3D scanning protocol that is designed to capture volumetric tissue dynamics tomography images only in a few tens of seconds. The method was applied to the evaluation of a tumor spheroid. The time-course viability alteration and anti-cancer drug response of the spheroid were visualized qualitatively and analyzed quantitatively. The similarity between the OCT-based dynamics images and fluorescence microscope images was also demonstrated.

Spatial resolution in conventional optical microscopy has traditionally been treated as a fixed parameter of the optical system. Here, we present an approach to enhance transverse resolution in beam-scanned optical coherence tomography (OCT) beyond its aberration-free resolution limit, without any modification to the optical system. Based on the theorem of invariance of information capacity, resolution-enhanced (RE)-OCT navigates the exchange of information between resolution and signal-to-noise ratio (SNR) by exploiting efficient noise suppression via coherent averaging and a simple computational bandwidth expansion procedure. We demonstrate a resolution enhancement of 1.5relative to the aberration-free limit while maintaining comparable SNR ...

Polarization-sensitive optical coherence tomography (PS-OCT) reveals the subsurface microstructure of biological tissue and provides information regarding the polarization state of light backscattered from tissue. Complementing OCT's structural signal with molecular imaging requires strategies to simultaneously detect multiple exogenous contrast agents with high specificity in tissue. Specific detection of molecular probes enables the parallel visualization of physiological, cellular, and molecular processes. Here we demonstrate that, by combining PS-OCT and spectral contrast (SC)-OCT measurements, we can distinguish signatures of different gold nanobipyramids (GNBPs) in lymphatic vessels from the surrounding tissue and blood vessels in live mouse models. This technique could ...

Notal Vision, Inc. reported today that results of the first U.S.-based feasibility study with its investigational home-based optical coherence tomography (OCT) platform were presented at the Retina Society and the American Society of Retina Specialists (ASRS) annual meetings. The Notal Home OCT pipeline technology is designed to provide patient-initiated retinal OCT scans to support the management of patients with wet age-related macular degeneration (AMD), complementing existing standard of care treatments as well as emerging longer acting drugs and drug delivery systems. The study evaluated the ability of subjects with wet AMD to perform sequential daily self-imaging of their ...

Glannaventa Receives a 2021 NIH NCI SBIR Grant for $399,331 for development of an out-patient screening procedure for high-grade serous ovarian cancer enabled by Optical Coherence Tomography. The principal investigator is John Black. Below is a summary of the proposed work. This year, over 22,000 women in the U.S. will be diagnosed with ovarian cancer (OvCa), and ~14,000 will die from this disease. Approximately 9,000 of these deaths occur from high-grade serous epithelial cancer (HGSC) primarily because of our inability to detect the disease in its early stages. OvCa accounts for 2.5% of all ...

Full-field swept-source optical coherence tomography (FF-SS-OCT) is an emerging technology with potential applications in ophthalmic imaging, microscopy, metrology, and other domains. Here we demonstrate a novel method of multiplexing FF-SS-OCT signals using carrier modulation (CM). The principle of CM could be used to inspect various properties of the scattered light, e.g. its spectrum, polarization, Doppler shift, or distribution in the pupil. The last of these will be explored in this work, where CM was used to acquire images passing through two different optical pupils. The two pupils contained semicircular optical windows with perpendicular orientations, with each window permitting measurement ...

Epidermal three-dimensional (3D) topography/quantification have not been completely characterized yet. The recently developed line-field confocal optical coherence tomography (LC-OCT) provides real-time, high-resolution, in-vivo 3D imaging of the skin. This pilot study aimed at quantifying epidermal metrics [epidermal thicknesses, dermal-epidermal junction (DEJ) undulation and keratinocyte number/shape/size] using 3D LC-OCT. For each study participant (8 female, skin-type-II, younger/older volunteers), seven body sites were imaged with LC-OCT. Epidermal metrics were calculated by segmentations and measurements assisted by artificial intelligence (AI) when appropriate. Thicknesses of epidermis/SC, DEJ undulation and keratinocyte nuclei volume varied across body sites. Evidence of keratinocyte ...

We propose and demonstrate an all-fiber Er-doped mode-locked laser with a 3-dB spectrum of 114 nm by using nonlinear polarization rotation (NPR), which to the best of our knowledge is the first realization to date of such a broad spectrum without any spatial optical devices. The repetition rate and pulse width of the laser are 183.6 MHz and 3.7 ps, respectively. Such an all-fiber NPR mode-locked laser is then applied in time-stretch optical coherence tomography. The axial resolution is 12.1 m. The all-fiber high speed broadband swept laser based on the time stretching technique has compact structure ...

This free, live event will take place on October 6 th, 10 EDT (4 PM CET) and will include an interactive QA session. For information and to register please visit this link. After the event a recorded version will be available at www.thorlabs.com/webinars . Abstract: Drs. Elizabeth Olson and Elliott Strimbu from Columbia University will highlight Phase Sensitive Spectral Domain Optical Coherence Tomography as it relates to nanoscale vibrometry. They will cover in detail the performance parameters of a Thorlabs Telesto for nanoscale displacement measurements in the cochlea and leverage their years of experience in the field ...

Luneau Technology Group announced that its merger with Optovue Inc. will enable the two companies to offer a comprehensive portfolio of health solutions to eye care providers. Were two agile companies with a startup mentality of innovation and flexibility, Marc Abitbol, PhD, CEO of the newly merged company, said in a press release. Together, we now have a full pipeline that covers everything for visual health. Optovues OCT expertise, stellar reputation and primary position in the medical eye care market and complementary portfolio of products make us an ideal partner, so our combined company can offer complete end-to-end ...

Classification of material type is crucial in the recycling industry since good quality recycling depends on the successful sorting of various materials. In textiles, the most commonly used fiber material types are wool, cotton, and polyester. When recycling fabrics, it is critical to identify and sort various fiber types quickly and correctly. The standard method of determining fabric fiber material type is the burn test followed by a microscopic examination. This traditional method is destructive, tedious, and slow since it involves cutting, burning, and examining the yarn of the fabric. We demonstrate that the identification procedure can be done nondestructively ...

Forward-viewing endoscopic optical coherence tomography (OCT) provides 3D imaging in vivo, and can be combined with widefield fluorescence imaging by use of a double-clad fiber. However, it is technically challenging to build a high-performance miniaturized 2D scanning system with a large field-of-view. In this paper we demonstrate how a 1D scanning probe, which produces cross-sectional OCT images (B-scans) and 1D fluorescence T-scans, can be transformed into a 2D scanning probe by manual scanning along the second axis. OCT volumes are assembled from the B-scans using speckle decorrelation measurements to estimate the out-of-plane motion along the manual scan direction. Motion within ...

Background Air pollution is an emerging key player in determining the residual risk of coronary events. However, pathophysiological mechanisms linking air pollution and coronary events have been not adequately investigated. Purpose We assessed the relationship between exposure to air pollutants and mechanisms of coronary instability evaluated by optical coherence tomography (OCT) in patients with acute coronary syndrome (ACS). Methods ACS patients undergoing OCT imaging were retrospectively selected. Mechanism of culprit lesion instability was classified as plaque rupture (PR) or intact fibrous cap (IFC) by OCT, and the presence of macrophage infiltrates (MI) and thin-cap fibroatheroma (TCFA) at the culprit ...

Background This study aimed to explore the characteristics of Optical coherence tomography (OCT) imaging for differentiating between benign and malignant lesions, and different pathological types of lung cancer in bronchial lesions, and to preliminarily evaluate the clinical value of OCT. Methods Patients who underwent bronchoscopy biopsy and OCT between February 2019 and December 2019 at the Chinese PLA General Hospital were enrolled in this study. White-light bronchoscopy (WLB), auto-fluorescence bronchoscopy (AFB) and OCT were performed at the lesion location. The main characteristics of OCT imaging for the differentiation between benign and malignant lesions and the prediction of the pathological classification ...

Hydration of contact lenses is an important parameter as it governs the oxygen transport to the cornea. Dehydration of contact lenses during lens wear causes discomfort due to dry eye and alterations in lens fitting characteristics. Terahertz (THz) imaging and optical coherence tomography (OCT) together can provide unique information about the hydration profile of the contact lens and its structure. Here, we present results that combine the information measured from OCT and THz systems on contact lenses which aid in determining the change in water content and thickness over time. Overlaid THz and OCT images that align well are shown ...

Objective: To evaluate the retinal and choroidal thicknesses in women with iron-deficiency anemia (IDA) by enhanced-depth imaging optical coherence tomography (EDI-OCT) and to compare the results with healthy controls. Methods: Forty reproductive-aged female patients who had IDA and 40 healthy female control were enrolled in the study. Laboratory data including serum hemoglobin (Hb), serum iron, ferritin, and mean corpuscular volume (MCV) were recorded. The average peripapillary retinal nerve fiber layer (pRNFL) thicknesses were measured for all study participants. The central retinal thickness (CRT) and choroidal thickness (CT) in the foveal region and 500 m in the nasal and temporal directions ...

A customized Optical Coherence Tomography Angiography (OCTA) algorithm and Orthogonal OCT (en-face and B-Scans) were used for longitudinal assessment of retina murine vascular and tissue remodeling comparing photoreceptor ablation and laser-induced Choroidal Neovascularization (CNV). In the mouse model, we utilized a combined OCTA/OCT technique to image and quantify morphological and vascular features of laser lesions over time. This approach enabled us to monitor and correlate the dynamics of retina vascular and tissue remodeling as evidenced by swelling, edema, and scarring. From the OCT B-Scans, three stages of inflammatory progression were identified: the early response occurring within hours to day ...

Purpose: To assess the generalisability and performance of a deep learning classifier for automated detection of gonioscopic angle closure in anterior segment optical coherence tomography (AS-OCT) images. Methods: A convolutional neural network (CNN) model developed using data from the Chinese American Eye Study (CHES) was used to detect gonioscopic angle closure in AS-OCT images with reference gonioscopy grades provided by trained ophthalmologists. Independent test data were derived from the population-based CHES, a community-based clinic in Singapore, and a hospital-based clinic at the University of Southern California (USC). Classifier performance was evaluated with receiver operating characteristic curve and area under the ...

The cornerstone of glaucoma diagnosis and monitoring relies on an assessment of optic nerve structure and function. Advancements in OCT have allowed glaucoma care providers to evaluate optic nerve structure to an unparalleled degree. Principally, three OCT-derived parameter categories may be used for this purpose: retinal nerve fiber layer (RNFL), macular and optic nerve head. For good reason, more weight is typically placed on RNFL and macular parameters than on optic nerve head parameters. However, a novel optic nerve head parameter, Bruchs membrane opening minimum rim width (BMO-MRW; Heidelberg Spectralis, Heidelberg Engineering), may also add value to ones ...

Purpose The purpose of this study was to examine whether racial and ethnic differences in retinal microvasculature are detectable with quantitative measures derived from optical coherence tomography angiography (OCTA). Methods OCTA scans and fundus photography were obtained in 447 eyes from 271 patients with and without diabetes between April and October 2018. Fundus photos were graded by the hospital reading center for diabetic retinopathy (DR) severity. Eight OCTA parameters relating to the foveal avascular zone (FAZ), superficial vascular perfusion, and deep vascular perfusion were analyzed for significant differences between race and ethnicity groups, self-reported by patients and organized according to ...

The University of Sheffield has two openings for 3-Year Post Doc positions in OCT within the Department of Electronic and Electrical Engineering with professor Stephen Matcher. See links below for more information: https://www.jobs.ac.uk/job/CKA945/research-associate-in-biophotonics https://www.jobs.ac.uk/job/CKB240/research-associate-in-biophotonics

Purpose Suboptimal functional outcomes following rhegmatogenous retinal detachment (RRD) repair may be related to photoreceptor abnormalities including alterations of the ellipsoid zone (EZ) which may not be apparent on cross-sectional optical coherence tomography (OCT). This study assessed EZ recovery using en face OCT following RRD repair and its association with visual acuity. Design Post hoc analysis of a randomized controlled trial. Methods Patients with macula-off RRD were followed at 3, 6, 12 and 24 months post-operatively and annually thereafter. En face OCT of the EZ slab were analyzed. Hyporeflective areas were co-localized with EZ abnormalities on cross-sectional OCT B-Scans and ...

Purpose: The causes of floaters include posterior vitreous detachment (PVD) and fundus hemorrhage, both of which are risk factors for retinal tears. We observed the vitreous of patients with floaters using SS-OCT. Methods: Fundus examination was performed and the vitreous was observed using SS-OCT in 202 eyes of 202 patients with floaters. Patients with uveitis, diabetic retinopathy, and other fundus diseases were excluded. Results: SS-OCT revealed PVD in 145 of 202 eyes (71.8%) and dot reflex like stardust in the vitreous in 42 of 202 eyes (20.8%). PVD occurred in 35 of 42 eyes (83.3%), 110 of ...

Optical Coherence Tomography (OCT) has become a standard of care for diagnos ing and monitoring eye diseases. However, d espite its rapid development , high - resolution in vivo imaging with penetration into deeper tissue layers is still a major challenge for classical OCT . Namel y, OCT is limited by the presence of coherent noise that is due to the use of spatially coherent lasers, necessary for scanning and confocal detection . The noise, which mani fest itself as speckle or crosstalk, effectively limit s the achievable imaging depth and spatial resolution, which in turn reduce its diagnostic capabilities . Recently, to speed up ...

Background Stent under-expansion obtained at the time of percutaneous coronary intervention (PCI) has been shown to be associated with worse outcomes. Purpose We sought to define OCT assessed optimal stent expansion index which associates with lower incidence of major adverse cardiac events (MACE) during follow-up in a sample of patients stented at five high volume centers of central Europe. Methods We analyzed 370 lesions stented during the period between 2012 and 2018, with their final procedural results imaged using optical coherence tomography (OCT). QIvus Research Edition v3.1 (Medis, Leiden, NL) was used for OCT analysis. The stented segment was ...