Journal of Neurophysiology

Time 2020-09-23 12:03:23

Web Name: Journal of Neurophysiology

WebSite: http://jn.physiology.org

ID:56908

Keywords:

Journal,of,Neurophysiology,

Description:

NEURO FORUMControl of MovementComponents of complex movement that can be best studied using the sequence learning paradigmReshma Babu2020 Aug 24: 645-647https://doi.org/10.1152/jn.00769.2019Control of MovementRole of the somatosensory cortex in motor memory consolidationManasi Wali2020 Aug 24: 648-651https://doi.org/10.1152/jn.00770.2019RESEARCH ARTICLESAuditory and Vestibular EfferentsActivation of GABAB receptors results in excitatory modulation of calyx terminals in rat semicircular canal cristaeYugandhar Ramakrishna and Soroush G. Sadeghi2020 Sep 14: 962-972https://doi.org/10.1152/jn.00243.2020Using in vitro whole cell patch-clamp recordings from calyx terminals in the vestibular end organs, we show that activation of GABAB receptors result in an excitatory effect, with decreased spike-frequency adaptation and shortened first-spike latencies. Our results suggest that these effects are mediated through inhibition of calcium-sensitive potassium channels.Cellular and Molecular Properties of NeuronsBK potassium currents contribute differently to action potential waveform and firing rate as rat hippocampal neurons mature in the first postnatal weekMichael S. Hunsberger and Michelle Mynlieff2020 Aug 24: 703-714https://doi.org/10.1152/jn.00711.2019This work describes the early developmental trends of large-conductance calcium-activated potassium (BK) channel activity. Early developmental trends in expression of BK channels, both total expression and relative isoform expression, have been previously reported, but little work describes the effect of these changes in expression patterns on excitability. Here, we show that early changes in BK channel expression patterns lead to changes in the role of BK channels in determining the action potential waveform and neuronal excitability. LRRK2 mutation alters behavioral, synaptic, and nonsynaptic adaptations to acute social stress - How does a common Parkinson's Disease-linked mutation affect stress response? In this podcast, Editor-in-Chief Bill Yates talks with Christopher Guevara, Dr. Bridget Matikainen-Ankney, Dr. Deanna Benson, and Dr. George Huntley (Icahn School of Medicine at Mount Sinai) about their Rapid Report article, which explored this question in a mouse model of the LRRK2-G2019S mutation. Listen to learn about evidence of how "G2019S alters the magnitude and direction of behavioral responses to stress that may reflect unique modifications of adaptive plasticity in cells and circuits implicated in psychopathology in humans." Read the article: 10.1152/jn.00137.2020 Comparative gain-of-function effects of the KCNMA1-N999S mutation on human BK channel properties - In this podcast, Editor-in-Chief Bill Yates talks with Dr. Andrea Meredith and Dr. Hans Moldenhauer about their article which compares the effects of different mutations (N999S and D434G) which are associated with the recently-identified neurological disorder called KCNMA1-linked channelopathy. This research was also featured in Episode 4 of the Netflix and New York Times documentary series Diagnosis. Listen to learn about BK channels, gain-of-function mutations, and important clinical implications of this research! Read the article: 10.1152/jn.00626.2019 What exactly is corporeal awareness, and how does breathing contribute to this form of self-consciousness? - In this podcast, Editor-in-Chief Bill Yates talks with Alessandro Monti, Dr. Giuseppina Porciello, Dr. Gaetano Tieri, and Dr. Salvatore M. Aglioti (Sapienza Università di Roma and IRCCS Fondazione Santa Lucia) about their Rapid Report article, which combined respiration recordings with immersive virtual reality to explore this question. Listen to learn about the embreathment illusion, which emerged from this unique experimental design. Read the article: 10.1152/jn.00617.2019 Estradiol rapidly modulates excitatory synapse properties in a sex- and region-specific manner in rat nucleus accumbens core and caudate-putamen - How does estradiol acutely facilitate sex differences in striatum-dependent behaviors? In this podcast, Editor-in-Chief Bill Yates talks with Dr. Amanda Krentzel and Dr. John Meitzen (both from North Carolina State University) about their study which investigated this question in adult rats. Listen to learn about sex differences, medium spiny neurons, glutamatergic signaling, and more. Also be sure to look out for the parallel episode of The Brain That Named Itself podcast, which will discuss this study in a way that is friendly to non-scientists! Read the article: 10.1152/jn.00264.2019 Between-hand coupling during response inhibition - The interference effect occurs during a bimanual response when one hand is abruptly cued to stop, resulting in a significant delay in the actions of the other hand. But what neural mechanisms underlie this effect? In this podcast, Editor-in-Chief Bill Yates talks with Corey Wadsley, Dr. John Cirillo, and Dr. Winston Byblow (all from the University of Auckland) about their recent article, which investigates whether the interference effect is the consequence of between-hand coupling. Listen to learn about the role of GABA-mediated networks, movement preparation, paradoxical findings and more! Read the article: 10.1152/jn.00310.2019 Behavioral training of marmosets and electrophysiological recording from the cerebellum - The marmoset is a promising new model for study of neurophysiological basis of behavior in primates. But will researchers ever be able to obtain enough trials per session to improve the practical utility of this model? In this podcast, Editor-in-Chief Bill Yates talks with Ehsan Sedaghat-Nejad, Paul Hage, and Dr. Reza Shadmehr (all from Johns Hopkins University) about their Innovative Methodology article, which introduces new behavioral training and neurophysiological protocols aimed at increasing the number of trials per session while recording from the cerebellum. Listen to learn about training efficacy, targeted multi-channel recording, and more! Read the article: 10.1152/jn.00389.2019 Pairing vagus nerve stimulation with tones drives plasticity across the auditory pathway - Previous studies have reported primary auditory cortex plasticity following vagus nerve stimulation (VNS) paired with a sound. Does this phenomenon extend to other fields in the auditory pathway? In this podcast, Editor-in-Chief Bill Yates talks with Dr. Michael S. Borland and Dr. Crystal Engineer (both from the University of Texas at Dallas) about their recent study, which is the first to to document both cortical and subcortical plasticity following VNS-sound pairing. Listen to learn about auditory plasticity, potential therapies for auditory processing disorders, and more! Read the article: 10.1152/jn.00832.2018 Cannabinoid receptor-mediated modulation of inhibitory inputs to mitral cells in the main olfactory bulb - What is the role of cannabinoid receptor type 1 (CB1) in olfactory processing? In this podcast, Editor-in-Chief Bill Yates talks with Thomas Heinbockel (Howard University) and Alex Straiker (Indiana University, Bloomington) about their recent study in mice, which revealed that CB1 is involved in the regulation of glomerular activity in the main olfactory bulb (MOB). Listen to learn about the endocannabinoid system, mitral cells, implications for olfactory behavior, and more! Read the article: 10.1152/jn.00100.2018

TAGS:Journal of Neurophysiology 

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The Journal of Neurophysiology publishes original articles on the function of the nervous system. All levels of function are included, from the membrane and cell to systems and behavior. Experimental approaches include molecular neurobiology, cell culture and slice preparations, membrane physiology, developmental neurobiology, functional neuroanatomy, neurochemistry, neuropharmacology, systems electrophysiology, imaging and mapping techniques, and behavioral analysis.

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