Alzheimer鈥檚 Disease (AD) is a neurodegenerative disorder affecting millions of elderly worldwide, and for which there is no cure yet. Biomarkers in body fluids such as the cerebrospinal fluid are supportive of the biological diagnosis of AD, but blood based biomarkers would have the preference, being obtained by low-invasive procedures. We here set out to identify AD specific peptides and proteins in plasma using analytical separation combined with in-depth mass spectrometry methods. We compared the profiles in AD patients compared to those obtained in healthy controls and patients with various diseases, in order to reveal disease specific patterns using elaborated statistical methods. The clinical groups thus included were: normals, multiple sclerosis, ovarian cancer, breast cancer, female normal, sepsis, ICU Control, heart attack, along with their institution-matched controls. The study revealed a multitude of differentially regulated proteins in plasma of AD patients, including brain specific and neuronal specific proteins. The study shows the feasibility of the approach, and indicates that there are several plasma proteins that merit to be studied in the course of this disease as potential biomarkers.

Authors: Mamatha Bhat, Sergi Clotet-Freixas, Cristina Baciu, Elisa Pasini, Ahmed Hammad, Tommy Ivanics, Shelby Reid, Amirhossein Azhie, Marc Angeli, Anand Ghanekar, Sandra Fischer, Gonzalo Sapisochin and Ana Konvalinka

Content type: Research

18 November 2021

Authors: Patricia Connolly, Sharon Stapleton, Gohar Mosoyan, Ilya Fligelman, Ya-Chen Tonar, Fergus Fleming and Michael J. Donovan

Content type: Research

17 November 2021

Authors: Kiran K. Mangalaparthi, Sandip Chavan, Anil K. Madugundu, Santosh Renuse, Patrick M. Vanderboom, Anthony D. Maus, Jennifer Kemp, Benjamin R. Kipp, Stefan K. Grebe, Ravinder J. Singh and Akhilesh Pandey

Content type: Letter to the editor

22 October 2021

Authors: Ruikun Zhang, Kun Yan, Yulun Wu, Xinmiao Yao, Guijin Li, Linpu Ge and Zhineng Chen

Content type: Research

12 October 2021

Authors: K. Egervall, A. Rosso and S. Elmst氓hl

Content type: Research

28 September 2021

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Authors: Hu Zhao, Yaojun Li and Ye Hu

Content type: Review

13 May 2014

Authors: Anna K F眉z茅ry, Joshua Levin, Maria M Chan and Daniel W Chan

Content type: Review

2 October 2013

Authors: Sameh Magdeldin, Shymaa Enany, Yutaka Yoshida, Bo Xu, Ying Zhang, Zam Zureena, Ilambarthi Lokamani, Eishin Yaoita and Tadashi Yamamoto

Content type: Review

15 April 2014

Authors: Somchai Chutipongtanate, Channarong Changtong, Churat Weeraphan, Suradej Hongeng, Chantragan Srisomsap and Jisnuson Svasti

Content type: Research

6 June 2015

Authors: Danni L Meany and Daniel W Chan

Content type: Review

3 June 2011

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In 2011, Clinical Proteomics converted from a subscription publication to a fully open access journal.The journal's back content can be viewed on SpringerLink.

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Clinical Proteomics encompasses all aspects of translational proteomics. Special emphasis will be placed on the application of proteomic technology to all aspects of clinical research and molecular medicine. The journal is committed to rapid scientific review and timely publication of submitted manuscripts.

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Dr Daniel W Chanis currently Professor of Pathology, Oncology, Urology, and Radiology at Johns Hopkins Medical Institutions, and Director of the Clinical Chemistry Division, Co-Director at the Pathology Core Laboratory, and Director at the Center for Biomarker Discovery and Translation at the Johns Hopkins University School of Medicine. He has worked extensively on the development and application of proteomic and immunologic techniques in the understanding of cancer. As the author of five books and over 300 articles, Dr Chan has become established as a leading expert in clinical proteomics and cancer research. Dr Chan is an active member of US Human Proteome Organization (USHUPO), American Association for Cancer Research (AACR) and American Association for Clinical Chemistry (AACC).

PediOme

Guest edited by Vera Ignjavtovic, Allen Everett and Hanno Steen

The Paediatric Proteomics (PediOme) is an initiative of HUPO that aims to advance the use of proteomic techniques to solve major issues in Paediatric medicine.

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Proteomics in India

Guest edited by Harsha Gowda and Akhilesh Pandey

This collections features the latest advances in Proteomics research from India.

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Glycoproteomics and glycomics

Guest edited by Punit Shah and Hui Zhang

This thematic series publishes both solicited and unsolicited content on the topic of protein glycosylation; one of the most common protein modifications in both normal biological processes and diseases. This series focuses on glycoproteomic or glycomic methods and their clinical applications.

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