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Nolvadex drug belongs to the group of anti-tumor drugs. However, this drug is widely used men who are engaged in bodybuilding and want to pump up muscles. Since Nolvadex contains an active ingredient tamoxifen, which is a selective estrogen receptor modulator mixed agonistic and antagonistic properties. This means that in certain tissue, they block the action of estrogen receptors by binding, while in other tissues could act as a real estrogen receptors activating. In men, both drugs act as anti-estrogens in their ability to interfere with estrogen negative feedback on the hypothalamus and stimulate the increased production of GnRH (gonadotropin-releasing hormone). This will result in increased production of luteinizing hormone by the pituitary gland, which in turn can increase the production of testosterone by the testes. This makes both drugs, but for some reason bodybuilders continue to think that only Clomid is well suited to the stimulation of testosterone.

According to studies of the drug, the effect of Nolvadex and Clomid on the endocrine system of healthy men suffering from low sperm counts (oligospermia), have shown the benefits of Nolvadex over Clomid to increase testosterone levels. The drug also has no effect on the blood level of estrogens because its mechanism of action is also reduced to the estrogen receptor blockade, including the pituitary gland. However, Nolvadex - less selective as compared to other drugs of this series. Nolvadex binds to estrogen receptors in almost all the body. In bone tissue, tamoxifen activates the estrogen receptors.

Nolvadex blocks the receptors in almost all tissues and helps to ensure that the body began to rebuild its own testosterone. Importantly, Nolvadex capable of blocking estrogen receptors in the pituitary less drug than Clomid. Nolvadex does not affect the metabolism of estrogenic hormones, so the intake of estrogens these means continue to erode the liver enzymes, and do not accumulate in the body.

Taking the drug with caution, since toxic and Nolvadex belongs to the group of the banned doping agents. Although it is widely used in bodybuilding men. Also, this pills is antiestrogen, an antitumor agent based on active ingredient tamoxifen for the treatment of malignant tumors of breast and endometrial malignancy.