The New England Journal of Medicine: Research Review Articles on Disease Clinical Practice

Time 2020-06-17 06:05:44

Web Name: The New England Journal of Medicine: Research Review Articles on Disease Clinical Practice

WebSite: http://www.nejm.org

ID:2594

Keywords:

Journal,of,Medicine,

Description:

NEJM Journal Watch Concise summaries and expert physician commentary that busy clinicians need to enhance patient care. NEJM Knowledge + The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. NEJM Catalyst NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery. NEJM Resident 360 Information, resources, and support needed to approach rotations - and life as a resident. NEJM Career Center Valuable tools for building a rewarding career in health care. NEJM Library Hub Information and tools for librarians about site license offerings. NEJM 医学前沿 The authorized source of trusted medical research and education for the Chinese-language medical community. The New England Journal of Medicine The most trusted, influential source of new medical knowledge and clinical best practices in the world. Subscribe to the most trusted and influential source ofmedical knowledge Due to scheduled maintenance, account functionality on NEJM.org will be temporarily offline for up to 1 hour between 1:00 AM ET-5:00 AM ET Wednesday, June 17. All content will be available, but transactions and other account updates will be temporarily offline. We apologize for the inconvenience. Facing the Monster in Haiti V. Rouzier, B. Liautaud, and M.M. Deschamps Lacking international support, clinicians in Haiti have implemented practical solutions to coordinate laboratory testing for Covid-19, provide education and training, and overcome public mistrust and stigma. Jun 16 Natural History of Asymptomatic SARS-CoV-2 Infection A. Sakurai and Others The outbreak on the cruise ship Diamond Princess led to the identification of 96 persons who were infected with SARS-CoV-2 but were asymptomatic. This report describes their course during isolation, with close observation and serial tests for the virus. Jun 12 Givosiran for Acute Intermittent Porphyria M. Balwani and Others In a randomized phase 3 trial involving patients with acute intermittent porphyria, the use of givosiran, an oligonucleotide drug designed to target messenger RNA encoding aminolevulinic acid synthase, led to a 74% lower annualized porphyria attack rate than the use of placebo at 6 months. Jun 11 EditorialGivosiran Running RNA Interference to Fight Porphyria Attacks Brain Autopsy Series in Patients with Covid-19 I.H. Solomon and Others Eighteen brains of patients who died 0 to 32 days after the onset of symptoms of SARS-CoV-2 infection showed hypoxic ischemic changes but no encephalitis, meningitis, strokes, or changes in olfactory bulbs or tracts. Low viral counts were detected by quantitative RT-PCR in a few brain sections, and no virus was evident on immunohistochemical analysis. Jun 12 Th2 Cytokine Blockade in Coccidioidomycosis M. Tsai and Others Disseminated coccidioidomycosis that was unresponsive to antifungal antibiotics developed in a child later found to have defective interleukin-12 signaling. Addition of interferon- and dupilumab, an antibody to block the interleukin-4 and interleukin-13 receptor, led to resolution of lesions in the skeleton, lungs, soft tissues, and nodes. Jun 11 Relugolix for Androgen-Deprivation Therapy N.D. Shore and Others Luteinizing hormone releasing hormone agonists that are used in androgen-deprivation therapy have a slow onset to suppress testosterone levels, and the level of suppression may be incomplete. This randomized trial assessed relugolix, an oral gonadotropin-releasing hormone antagonist with rapid onset, profound suppression of testosterone levels, and rapid recovery after cessation. Jun 04 Original ArticleEnzalutamide and Survival in Nonmetastatic, Castration-Resistant Prostate CancerEditorialCardiovascular Disease and Androgen Axis Targeted Drugs for Prostate Cancer Rituximab and Chemotherapy in Pediatric High-Grade Lymphoma V. Minard-Colin and Others The addition of rituximab to standard combination chemotherapy in children with high-grade (mainly Burkitt s) lymphoma improved 3-year event-free survival (94% vs. 82%). The incidence of myelotoxic effects was somewhat higher, without a higher incidence of death from toxic effects; the incidence of hypogammaglobulinemia was higher. Jun 04 Tofacitinib for Autoimmune Colitis from Anti-PD1 K. Esfahani, M. Hudson, and G. Batist Tofacitinib is a JAK inhibitor that decreases cytokine production. In a woman with autoimmune colitis from the administration of pembrolizumab to treat her cancer, tofacitinib induced remission in 5 days, after glucocorticoids, infliximab, and vedolizumab had been ineffective. The cancer responded to immunotherapy, and the autoimmune complication resolved with tofacitinib. Jun 11 Cardiovascular Consequences of Acute Kidney Injury M. Legrand and P. Rossignol Acute kidney injury is associated with many short- and long-term adverse events. This review considers the cardiovascular consequences and strategies that can be used during acute kidney injury and recovery, with the aim of reducing subsequent cardiovascular risks. Jun 04 Dynamic Developments in Screening Candidate Drugs J.M. Parks and J.C. Smith Molecular-dynamics simulations together with virtual high-throughput screening provide a means of quick evaluation of existing drugs for antiviral activity. The authors explain how these methods serve in the quest for drugs to treat Covid-19. Jun 04 What are the top three challenges to successful implementation of interventions designed to address patients’ health-related social needs? Lack of resources to address patient needs (either in the organization or in the community) Lack of resources (e.g., time or personnel) to effectively screen patients Lack of coordination with community-based organizations Absence of actionable data and appropriate metrics to measure performance Lack of knowledge of how to screen and/or respond to identified needs Lack of integration with provider organizations Lack of effective screening tools Learn about the Insights Council

TAGS:Journal of Medicine 

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The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.

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