RIFM Home | FCT

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Web Name: RIFM Home | FCT

WebSite: http://fragrancematerialsafetyresource.elsevier.com

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To access the Safety Assessment Sheet, use the pull down menu above to search by either CAS number or chemical name or synonym. The purpose of the RIFM safety assessment is to assure the safe use of fragrance materials in consumer products. Assessments of the data supporting the safe use of fragrance materials follow the updated Criteria Document. The Criteria Document provides guidance on conducting safety assessments and is designed to incorporate the best science to appropriately evaluate fragrance ingredients using the latest testing strategies and methods. The assessments may be found by using the search feature above. Previously published assessments may be found at the links below. For more information about the Research Institute for Fragrance Materials, visit www.rifm.org.  Click here to learn more about the Creme RIFM Aggregate Exposure Model and the Quantitative Risk Assessment (QRA2). Learn how QRA2 changed from QRA1, how we use the Creme RIFM Model in the QRA2 and how the Creme RIFM Aggregate Exposure Model is used to derive Maximum Acceptable Concentrations based on all toxicological endpoints in the RIFM Safety Assessments. Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) Safety Evaluation Process for Fragrance Ingredients Api AM, Belsito D, Bruze M, et al This Criteria Document details recent updates to the RIFM safety assessment process, reflecting advances in approaches in risk assessment and new and classical toxicological methodologies employed by RIFM over the past 10 years. These changes include incorporating:New scientific information including a framework for choosing structural analogsConsideration of the Threshold of Toxicological Concern (TTC)Quantitative Risk Assessment (QRA) for dermal contact sensitizationRespiratory route of exposureAggregate exposure assessment methodologyLatest methodology and approaches to risk assessmentsLatest alternatives to animal testing methodologyEnvironmental risk assessment Read More The Safety Assessment of Fragrance Materials Bickers DR, Calow P, Greim HA, et alSafety evaluation of the large number of diverse chemicals used as fragrance ingredients follows a systematic prioritization of data generation and analysis, consideration of exposure and critical analysis of the quality of the available information. READ MORE Criteria for Development of a Database for Safety Evaluation of Fragrance Ingredients Ford RA, Domeyer B, Easterday O, et alOver 2000 different ingredients are used in the manufacture of fragrances. The majority of these ingredients have been used for many decades. READ MORE Consumer Exposure to Fragrance Ingredients: Providing Estimates for Safety Evaluation Peter A. Cadby, William R. Troy, Matthias G. H. VeyTo fully apply already published procedures for the safety evaluation of fragrance ingredients, it is necessary to estimate exposure through different routes and leading to different potential endpoints. READ MORE A framework for prioritizing fragrance materials for aquatic risk assessment.Salvito DT, Senna RJ, Federle TW. Environ Toxicol Chem. 2002;21:1301-1308. READ MORE Design and feasibility of an international study assessing the prevalence of contact allergy to fragrances in the general population: The European Dermato-Epidemiology Network Fragrance Study.Rossi M, Coenraads PJ, Diepgen T, et al.  Dermatology. 2010;221:267-275. READ MORE Prevalence of self-reported skin complaints and avoidance of common daily life consumer products in selected European Regions.Naldi L, Cazzaniga S, Gonçalo M, et al.  JAMA Dermatol. 2014;150:154-163. READ MORE Register here to be notified when new Safety Assessment Sheets are added to this site. Your email address will only be used to notify you of updates to this site. You may opt out at any time. Integrating Habits and Practices Data for Soaps, Cosmetics and Air Care Products into an Existing Aggregate Exposure Model Comiskey D, Api AM, Barrett C, et alIn order to accurately assess aggregate exposure to a fragrance material in consumers, data are needed on consumer habits and practices, as well as the concentration of the fragrance material in those products. READ MORE Application of the Expanded Creme RIFM Consumer Exposure Model to Fragrance Ingredients in Cosmetic, Personal Care and Air Care Products Safford B, Api AM, Barrett C, et alAs part of a joint project between the Research Institute for Fragrance Materials (RIFM) and Crème Global, a Monte Carlo model (here named the Creme RIFM model) has been developed to estimate consumer exposure to ingredients in personal care products. READ MORE Novel Database for Exposure to Fragrance Ingredients in Cosmetics and Personal Care Products Comiskey D, Api AM, Barratt C, et alExposure of fragrance ingredients in cosmetics and personal care products to the population can be determined by way of a detailed and robust survey. READ MORE Use of an Aggregate Exposure Model to Estimate Consumer Exposure to Fragrance Ingredients in Personal Care and Cosmetic Products Safford B, Api AM, Barratt C, et alEnsuring the toxicological safety of fragrance ingredients used in personal care and cosmetic products is essential in product development and design, as well as in the regulatory compliance of the products. READ MORE Extension of the Dermal Sensitisation Threshold (DST) Approach to Incorporate Chemicals Classified as Reactive Safford RJ, Api AM, Roberts DW, Lalko JFThe evaluation of chemicals for their skin sensitising potential is an essential step in ensuring the safety of ingredients in consumer products. READ MORE Principles for identification of High Potency Category Chemicals for Which the Dermal Sensitisation Threshold (DST) Approach Should Not be Applied Roberts DW, Api AM, Safford RJ, Lalko JFAn essential step in ensuring the toxicological safety of chemicals used in consumer products is the evaluation of their skin sensitising potential. READ MORE Dermal Sensitization Quantitative Risk Assessment (QRA) for Fragrance Ingredients Api AM, Basketter DA, Cadby PA, et alBased on chemical, cellular, and molecular understanding of dermal sensitization, an exposure-based quantitative risk assessment (QRA) can be conducted to determine safe use levels of fragrance ingredients in different consumer product types. READ MORE Implementation of the Dermal Sensitization Quantitative Risk Assessment (QRA) for Fragrance Ingredients Api AM, Vey MSignificant developments have recently been incorporated in the way dermal sensitization risk assessments are conducted for fragrance ingredients. READ MORE The Research Institute for Fragrance Materials’ Human Repeated Insult Patch Test Protocol Politano VT, Api AMWith implementation of the dermal sensitization QRA approach for fragrance ingredients, IFRA/RIFM are recommending use of the RIFM standard human repeated insult patch test (HRIPT) protocol for generation of confirmatory human data for the induction of dermal sensitization in a normal human population. READ MORE Click here to learn about 50 years of innovation in the safety assessment of raw fragrance matials, the role of RIFM’s Expert Panel, and the latest method of calculating aggregate exposure in consumers. Click here to join a panel of experts as they detail the latest updates to the criteria used to evaluate the safety of fragrance ingredients. Comparison of Cramer Classification between Toxtree, the OECD QSAR Toolbox and Expert Judgment Bhatia S, Schultz T, Roberts D, et alThe Threshold of Toxicological Concern (TTC) is a pragmatic approach in risk assessment. In the absence of data, it sets up levels of human exposure that are considered to have no appreciable risk to human health. READ MORE An in silico Skin Absorption Model for Fragrance Materials Shen J, Kromidas L, Schultz T, Bhatia SFragrance materials are widely used in cosmetics and other consumer products. The Research Institute for Fragrance Materials (RIFM) evaluates the safety of these ingredients and skin absorption is an important parameter in refining systemic exposure. READ MORE

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