Rare Cancer News & Clinical Trials

Time 2021-10-20 12:03:49

Web Name: Rare Cancer News & Clinical Trials

WebSite: http://news.rare-cancer.org

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Not logged in|Login skip to content Rare Cancer News DocWire News Selection of DNA Aptamers Recognizing EpCAM-Positive Prostate Cancer b | DDDT - Dove Medical Press Posted: September 20th, 2021, 4:23pm GMT Selection of DNA Aptamers Recognizing EpCAM-Positive Prostate Cancer b | DDDTDove Medical Press Testing for EGFR mutations and ALK rearrangements | OTT - Dove Medical Press Posted: August 31st, 2021, 3:02pm GMT Testing for EGFR mutations and ALK rearrangements | OTTDove Medical Press Effect of Liraglutide on Islet Function in Type 2 Diabetes | DMSO - Dove Medical Press Posted: August 31st, 2021, 12:15pm GMT Effect of Liraglutide on Islet Function in Type 2 Diabetes | DMSODove Medical Press What to trust, PSA or [68Ga]PSMA-11: learn from experience | RRU - Dove Medical Press Posted: August 20th, 2021, 5:00am GMT What to trust, PSA or [68Ga]PSMA-11: learn from experience | RRUDove Medical Press Rare Tumor-to-Tumor Metastasis Takes an Unusual Direction - MedPage Today Posted: August 16th, 2021, 4:03pm GMT Rare Tumor-to-Tumor Metastasis Takes an Unusual DirectionMedPage Today Sjögren Syndrome Induced by Immune Checkpoint Inhibitors in a Patient with Advanced Renal Cell Carcinoma - Cancer Network Posted: August 14th, 2021, 10:06am GMT Sjögren Syndrome Induced by Immune Checkpoint Inhibitors in a Patient with Advanced Renal Cell CarcinomaCancer Network Prostate Cancer Symptoms, Diagnosis, Screening, TreatmentHealthCentral.com László Tabár shares his latest thoughts on breast AI - AuntMinnie Europe Posted: August 10th, 2021, 5:10am GMT László Tabár shares his latest thoughts on breast AIAuntMinnie Europe László Tabár shares his latest thoughts on breast AI - AuntMinnie Europe Posted: August 10th, 2021, 5:10am GMT László Tabár shares his latest thoughts on breast AIAuntMinnie Europe Tumor-to-Tumor Metastasis: Lung Adenocarcinoma as a Recipient of Metastasis from Renal Cell Carcinoma: A Case Report - DocWire News Posted: August 9th, 2021, 1:02pm GMT Tumor-to-Tumor Metastasis: Lung Adenocarcinoma as a Recipient of Metastasis from Renal Cell Carcinoma: A Case ReportDocWire News Dimensional study of prostate cancer using stereological tools - DocWire News Posted: August 6th, 2021, 1:02pm GMT Dimensional study of prostate cancer using stereological toolsDocWire News Dimensional study of prostate cancer using stereological tools - DocWire News Posted: August 6th, 2021, 1:02pm GMT Dimensional study of prostate cancer using stereological toolsDocWire News Anophthalmic socket syndrome | OPTH - Dove Medical Press Posted: August 5th, 2021, 12:04pm GMT Anophthalmic socket syndrome | OPTHDove Medical Press Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer - pnas.org Posted: August 2nd, 2021, 5:29pm GMT Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancerpnas.org Heterochronous metastases of lung adenocarcinoma | OTT - Dove Medical Press Posted: July 22nd, 2021, 5:00am GMT Heterochronous metastases of lung adenocarcinoma | OTTDove Medical Press GWAS and Single-Cell Epigenomics Provide Insights Into Type 1 Diabetes - Genetic Engineering Genetic Engineering Biotechnology News Expression analysis of MIST1 and EMT markers - IJGM | IJGM - Dove Medical Press Posted: April 14th, 2021, 5:00am GMT Expression analysis of MIST1 and EMT markers - IJGM | IJGMDove Medical Press The role of autophagy in controlling SARS‐CoV‐2 infection: An overview on virophagy‐mediated molecular drug targets - Wiley Posted: April 5th, 2021, 5:00am GMT The role of autophagy in controlling SARS‐CoV‐2 infection: An overview on virophagy‐mediated molecular drug targetsWiley Identification of Critical Pathways and Potential Key Genes in Poorly | OTT - Dove Medical Press Posted: January 27th, 2021, 6:00am GMT Identification of Critical Pathways and Potential Key Genes in Poorly | OTTDove Medical Press Is This Really Cancer? | MedPage Today - MedPage Today Posted: January 8th, 2021, 6:00am GMT Is This Really Cancer? | MedPage TodayMedPage Today A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer: A case–control study - PLoS Blogs Posted: December 10th, 2020, 6:00am GMT A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer: A case–control studyPLoS Blogs How treatment helped Cannock policeman survive rare cancer longer than anyone else - expressandstar.com Posted: November 29th, 2020, 6:00am GMT How treatment helped Cannock policeman survive rare cancer longer than anyone elseexpressandstar.com ACSL3–PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression - Science Advances Posted: October 30th, 2020, 5:00am GMT ACSL3–PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progressionScience Advances What are the Differences Between Small Cell and Non-Small Cell Lung Cancer? - News-Medical.net Posted: August 17th, 2020, 5:00am GMT What are the Differences Between Small Cell and Non-Small Cell Lung Cancer?News-Medical.net Understanding the Molecular Pathology of Lung Cancer - News-Medical.net Posted: August 13th, 2020, 5:00am GMT Understanding the Molecular Pathology of Lung CancerNews-Medical.net Early Detection in a Mouse Model of Pancreatic Cancer by Imaging DNA Damage Response Signaling - Journal of Nuclear Medicine Posted: July 1st, 2020, 5:00am GMT Early Detection in a Mouse Model of Pancreatic Cancer by Imaging DNA Damage Response SignalingJournal of Nuclear Medicine Cancer at Nature Portfolio - Nature.com Posted: July 1st, 2020, 5:00am GMT Cancer at Nature PortfolioNature.com Cancer at Nature Portfolio - Nature.com Posted: July 1st, 2020, 5:00am GMT Cancer at Nature PortfolioNature.com FDA Grants Liposomal Irinotecan Fast Track Status for Frontline Metastatic Pancreatic Cancer - OncLive Posted: June 17th, 2020, 5:00am GMT FDA Grants Liposomal Irinotecan Fast Track Status for Frontline Metastatic Pancreatic CancerOncLive Eight-year Survivor's Success with Precision Medicine and a Clinical Trial - Pancreatic Cancer News Pancreatic Cancer News Stories Adenocarcinoma: Types, symptoms, and causes - Medical News Today Posted: February 14th, 2020, 11:57am GMT Adenocarcinoma: Types, symptoms, and causesMedical News Today Pancreatic cancer: Symptoms, causes, and treatment - Medical News Today Posted: February 13th, 2020, 7:51pm GMT Pancreatic cancer: Symptoms, causes, and treatmentMedical News Today Dual-Ligand Functionalized Core-Shell Chitosan-Based Nanocarrier for H | IJN - Dove Medical Press Posted: February 5th, 2020, 6:00am GMT Dual-Ligand Functionalized Core-Shell Chitosan-Based Nanocarrier for H | IJNDove Medical Press Cell Stiffness May Indicate Likelihood of Cancer Metastasis - Genetic Engineering Genetic Engineering Biotechnology News DNMT3a promotes proliferation by activating the STAT3 signaling pathwa | CMAR - Dove Medical Press Posted: July 10th, 2019, 5:00am GMT DNMT3a promotes proliferation by activating the STAT3 signaling pathwa | CMARDove Medical Press Acinic Cell Carcinoma - News-Medical.net Posted: June 18th, 2019, 5:00am GMT Acinic Cell CarcinomaNews-Medical.net Acinic Cell Carcinoma - News-Medical.net Posted: June 18th, 2019, 5:00am GMT Acinic Cell CarcinomaNews-Medical.net Stage 4 pancreatic cancer survivor shares inspiring story - KTRK-TV Posted: May 18th, 2019, 5:00am GMT Stage 4 pancreatic cancer survivor shares inspiring storyKTRK-TV Kaplan USMLE Step 1 prep: Woman has excessive thirst, urination - American Medical Association Posted: May 14th, 2019, 5:00am GMT Kaplan USMLE Step 1 prep: Woman has excessive thirst, urinationAmerican Medical Association Long noncoding RNA DLX6-AS1 promotes tumorigenesis by modulating miR-4 | CMAR - Dove Medical Press Posted: May 7th, 2019, 5:00am GMT Long noncoding RNA DLX6-AS1 promotes tumorigenesis by modulating miR-4 | CMARDove Medical Press Comparative study of the PD-L1 expression and CD8+ tumor-infiltrating | TCRM - Dove Medical Press Posted: May 1st, 2019, 5:00am GMT Comparative study of the PD-L1 expression and CD8+ tumor-infiltrating | TCRMDove Medical Press Microcalcifications in Breast Cancer - News-Medical.net Posted: February 26th, 2019, 6:00am GMT Microcalcifications in Breast CancerNews-Medical.net Systematic review of sequencing of ALK inhibitors in ALK-positive non- | LCTT - Dove Medical Press Posted: February 8th, 2019, 6:00am GMT Systematic review of sequencing of ALK inhibitors in ALK-positive non- | LCTTDove Medical Press Which Approach is Best for Biopsy Gleason Score 9–10 Prostate Cancer? - Cancer Network Posted: December 10th, 2018, 6:00am GMT Which Approach is Best for Biopsy Gleason Score 9–10 Prostate Cancer?Cancer Network Dad-of-three given months to live after being struck down with an incurable form of cancer - Wales Online Posted: November 11th, 2018, 6:00am GMT Dad-of-three given months to live after being struck down with an incurable form of cancerWales Online Rare Prostate Cancer Associated with Cushing's Syndrome in Case Report - Cushing's Disease News Posted: October 16th, 2018, 5:00am GMT Rare Prostate Cancer Associated with Cushing's Syndrome in Case ReportCushing's Disease News Scalp metastases as first presentation of pulmonary adenocarcinomas: a | OTT - Dove Medical Press Posted: September 21st, 2018, 5:00am GMT Scalp metastases as first presentation of pulmonary adenocarcinomas: a | OTTDove Medical Press Comparison and validation of the value of preoperative inflammation ma | CMAR - Dove Medical Press Posted: September 11th, 2018, 5:00am GMT Comparison and validation of the value of preoperative inflammation ma | CMARDove Medical Press ALK-rearrangement neuroendocrine carcinoma of the lung: a comprehensiv | OTT - Dove Medical Press Posted: August 17th, 2018, 5:00am GMT ALK-rearrangement neuroendocrine carcinoma of the lung: a comprehensiv | OTTDove Medical Press Pleiotropic functions of miR107 in cancer networks | OTT - Dove Medical Press Posted: July 18th, 2018, 5:00am GMT Pleiotropic functions of miR107 in cancer networks | OTTDove Medical Press Lung Adenocarcinoma: Overview and More - Verywell Health Posted: May 10th, 2018, 4:54am GMT Lung Adenocarcinoma: Overview and MoreVerywell Health Hydrogel microenvironments for cancer spheroid growth and drug screening - Science Advances Posted: April 27th, 2018, 5:00am GMT Hydrogel microenvironments for cancer spheroid growth and drug screeningScience Advances The role of miRNAs in the diagnosis, chemoresistance, and prognosis of | TCRM - Dove Medical Press Posted: January 25th, 2018, 6:00am GMT The role of miRNAs in the diagnosis, chemoresistance, and prognosis of | TCRMDove Medical Press FXR Bile Acid Receptor Attenuates Cell Autophagy in Chronic Pancreatitis Patients - News-Medical.net Posted: January 18th, 2018, 6:00am GMT FXR Bile Acid Receptor Attenuates Cell Autophagy in Chronic Pancreatitis PatientsNews-Medical.net Human Pancreatic Acinar Cells - Am J Pathology Posted: September 18th, 2017, 5:00am GMT Human Pancreatic Acinar CellsAm J Pathology A versatile 3D tissue matrix scaffold system for tumor modeling and drug screening - Science Advances Posted: September 13th, 2017, 5:00am GMT A versatile 3D tissue matrix scaffold system for tumor modeling and drug screeningScience Advances The secret to combating pancreatic cancer may lie in suppression of a common protein - Science Daily Posted: May 22nd, 2017, 5:00am GMT The secret to combating pancreatic cancer may lie in suppression of a common proteinScience Daily WY Firefighter's Family to Get Benefits Thanks to New Law - Firehouse.com Posted: April 25th, 2017, 5:00am GMT WY Firefighter's Family to Get Benefits Thanks to New LawFirehouse.com Casper fire captain dies of cancer, the first firefighter to qualify under new workers compensation law - Casper Star-Tribune Online Posted: April 24th, 2017, 5:00am GMT Casper fire captain dies of cancer, the first firefighter to qualify under new workers compensation lawCasper Star-Tribune Online Therapeutic Implications of Molecular Subtyping for Pancreatic Cancer - Cancer Network Posted: March 15th, 2017, 5:00am GMT Therapeutic Implications of Molecular Subtyping for Pancreatic CancerCancer Network UCSD helps lead ambitious study of 80 rare cancers - The San Diego Union-Tribune Posted: January 18th, 2017, 6:00am GMT UCSD helps lead ambitious study of 80 rare cancersThe San Diego Union-Tribune History and progression of Fat cadherins in health and disease | OTT - Dove Medical Press Posted: December 1st, 2016, 6:00am GMT History and progression of Fat cadherins in health and disease | OTTDove Medical Press Astellas laudin' claudin: $1.4B Ganymed buy after ASCO sees phase II 'Xtandi' and deliver - BioWorld Online Posted: November 2nd, 2016, 5:00am GMT Astellas laudin' claudin: $1.4B Ganymed buy after ASCO sees phase II 'Xtandi' and deliverBioWorld Online CCP Score Emerges as a Prognostic Marker in Resected Stage I Lung Cancer - Targeted Oncology Posted: November 1st, 2016, 5:00am GMT CCP Score Emerges as a Prognostic Marker in Resected Stage I Lung CancerTargeted Oncology Survival Outcomes in Gleason 9-10 PCa Similar With Radiation, Surgery - Renal and Urology News Posted: August 2nd, 2016, 5:00am GMT Survival Outcomes in Gleason 9-10 PCa Similar With Radiation, SurgeryRenal and Urology News Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA) - Nature.com Posted: April 20th, 2016, 5:00am GMT Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)Nature.com Micropapillary: A component more likely to harbour heterogeneous EGFR mutations in lung adenocarcinomas | Scientific Reports - Nature.com Posted: April 5th, 2016, 5:00am GMT Micropapillary: A component more likely to harbour heterogeneous EGFR mutations in lung adenocarcinomas | Scientific ReportsNature.com Endoscopic ultrasound-guided fine needle core biopsy for the diagnosis of pancreatic malignant lesions: a systematic review and Meta-Analysis | Scientific Reports - Nature.com Posted: March 10th, 2016, 6:00am GMT Endoscopic ultrasound-guided fine needle core biopsy for the diagnosis of pancreatic malignant lesions: a systematic review and Meta-Analysis | Scientific ReportsNature.com Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma | Scientific Reports - Nature.com Posted: March 4th, 2016, 6:00am GMT Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma | Scientific ReportsNature.com Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation | Scientific Reports - Nature.com Posted: March 2nd, 2016, 6:00am GMT Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation | Scientific ReportsNature.com Variation in KRAS driver substitution distributions between tumor types is determined by both mutation and natural selection | Scientific Reports - Nature.com Posted: February 23rd, 2016, 6:00am GMT Variation in KRAS driver substitution distributions between tumor types is determined by both mutation and natural selection | Scientific ReportsNature.com PNA lectin for purifying mouse acinar cells from the inflamed pancreas | Scientific Reports - Nature.com Posted: February 17th, 2016, 6:00am GMT PNA lectin for purifying mouse acinar cells from the inflamed pancreas | Scientific ReportsNature.com Photoacoustic monitoring of tumor and normal tissue response to radiation | Scientific Reports - Nature.com Posted: February 17th, 2016, 6:00am GMT Photoacoustic monitoring of tumor and normal tissue response to radiation | Scientific ReportsNature.com Three-dimensional Organotypic Culture Models of Human Hepatocellular Carcinoma | Scientific Reports - Nature.com Posted: February 16th, 2016, 6:00am GMT Three-dimensional Organotypic Culture Models of Human Hepatocellular Carcinoma | Scientific ReportsNature.com NES1/KLK10 gene represses proliferation, enhances apoptosis and down-regulates glucose metabolism of PC3 prostate cancer cells | Scientific Reports - Nature.com Posted: November 30th, 2015, 6:00am GMT NES1/KLK10 gene represses proliferation, enhances apoptosis and down-regulates glucose metabolism of PC3 prostate cancer cells | Scientific ReportsNature.com Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis | Scientific Reports - Nature.com Posted: November 16th, 2015, 6:00am GMT Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis | Scientific ReportsNature.com Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer | Scientific Reports - Nature.com Posted: November 4th, 2015, 6:00am GMT Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer | Scientific ReportsNature.com Aggressive Lung Adenocarcinoma Subtype May Require New Treatment Strategy - Memorial Sloan Kettering Cancer Center Posted: September 17th, 2015, 5:00am GMT Aggressive Lung Adenocarcinoma Subtype May Require New Treatment StrategyMemorial Sloan Kettering Cancer Center Site of Fluid Secretion in Small Airways | American Journal of Respiratory Cell and Molecular Biology - AJRCMB Posted: July 16th, 2015, 5:00am GMT Site of Fluid Secretion in Small Airways | American Journal of Respiratory Cell and Molecular BiologyAJRCMB Pathophysiological role of microRNA-29 in pancreatic cancer stroma | Scientific Reports - Nature.com Posted: June 22nd, 2015, 5:00am GMT Pathophysiological role of microRNA-29 in pancreatic cancer stroma | Scientific ReportsNature.com Caveolin-1 is Associated with Tumor Progression and Confers a Multi-Modality Resistance Phenotype in Pancreatic Cancer | Scientific Reports - Nature.com Posted: June 12th, 2015, 5:00am GMT Caveolin-1 is Associated with Tumor Progression and Confers a Multi-Modality Resistance Phenotype in Pancreatic Cancer | Scientific ReportsNature.com PET/CT for Pancreatic Malignancy: Potential and Pitfalls - Journal of Nuclear Medicine Technology Posted: June 1st, 2015, 5:00am GMT PET/CT for Pancreatic Malignancy: Potential and PitfallsJournal of Nuclear Medicine Technology Adult metanephric adenoma presumed to be all benign? A clinical perspective - BMC Cancer - BMC Blogs Network Posted: April 25th, 2015, 5:00am GMT Adult metanephric adenoma presumed to be all benign? A clinical perspective - BMC CancerBMC Blogs Network Chad Scott Strawn | Obituaries | theworldlink.com - Coos Bay World Posted: April 25th, 2015, 5:00am GMT Chad Scott Strawn | Obituaries | theworldlink.comCoos Bay World Multimodal Molecular Imaging of Integrin αvβ3 for In Vivo Detection of Pancreatic Cancer - Journal of Nuclear Medicine Posted: March 1st, 2014, 6:00am GMT Multimodal Molecular Imaging of Integrin αvβ3 for In Vivo Detection of Pancreatic CancerJournal of Nuclear Medicine Parotid Tumors in Children | American Academy of Pediatrics - AAP Grand Rounds Posted: February 1st, 2014, 6:00am GMT Parotid Tumors in Children | American Academy of PediatricsAAP Grand Rounds PubMed - Acinar Cell Carcinoma Exome Sequencing of Pancreatic Acinar Carcinoma Identified Distinctive Mutation Patterns Fetched: October 12th, 2021, 5:00am GMT by Yuanhang Liu

Pancreas. 2021 Aug 1;50(7):1007-1013. doi: 10.1097/MPA.0000000000001870.

ABSTRACT

OBJECTIVES: Pancreatic acinar cell carcinoma (ACC) is a rare pancreatic cancer. The advancement of treatment is hampered because of the limited knowledge of its molecular mechanism.

METHODS: Whole-exome sequencing was performed on DNA extracted from 11 pure ACC surgical samples. Potential germline variants were removed on the basis of polymorphic databases, alternative allele frequency, coverage depth, and Catalogue of Somatic Mutations in Cancer (COSMIC) annotations after variant calling procedure. Mutation profiles and signatures were assessed through the Mutational Patterns package.

RESULTS: A median of 34 somatic mutations were detected (range, 19-60). Three novel recurrent small deletions were identified. Common pancreatic ductal adenocarcinoma mutations or neuroendocrine tumor mutants were not found. FAT atypical cadherin 4, mucin 5B, titin, and zinc finger homeobox 3 were consistently mutated across 4 independent ACC studies. A high contribution of COSMIC mutational signature 1 was seen in ACC, indicating deamination of 5-methylcytosine. The majority of the patients had COSMIC signatures 6, 15, or 20, relating to defective DNA mismatch repair. Six patients showed COSMIC mutational signature 10 because of the altered activity of DNA polymerase epsilon.

CONCLUSIONS: Distinct mutational signatures pathways were found in ACC and targeting them may improve clinical outcome.

PMID:34629449 | PMC:PMC8516064 | DOI:10.1097/MPA.0000000000001870

Long-term outcome of pancreatic function following oncological surgery in children: Institutional experience and review of the literature Fetched: October 8th, 2021, 5:00am GMT by Giulia Bolasco

World J Clin Cases. 2021 Sep 6;9(25):7340-7349. doi: 10.12998/wjcc.v9.i25.7340.

ABSTRACT

BACKGROUND: Pancreatic neoplasms are uncommon in children and in most cases they are benign or have low malignant potential. Pancreatoblastoma and solid pseudopapillary tumor are the most frequent types in early and late childhood, respectively. Complete resection, although burdened by severe complications, is the only curative treatment for these diseases. Pancreatic surgery may result in impaired exocrine and endocrine pancreatic function. However, limited data are available on the long-term pediatric pancreatic function following surgical resection.

AIM: To investigate endocrine and exocrine pancreatic function and growth after oncological pancreatic surgery in a pediatric series.

METHODS: A retrospective analysis of all pediatric patients who underwent surgery for pancreatic neoplasm in our Institution from January 31, 2002 to the present was performed. Endocrine and exocrine insufficiency, auxological and fat-soluble vitamin status (A, D, E and clotting tests) were assessed at diagnosis and at every follow-up visit. Exocrine insufficiency was defined as steatorrhea with fecal elastase-1 200 µg/g stool, while endocrine insufficiency was identified as onset of Diabetes or Impaired Glucose Tolerance. Growth was evaluated based on body mass index (BMI) z-score trend.

RESULTS: Sixteen patients (12 girls and 4 boys, mean age 10.7 ± 5.3 years), were included. Nine patients (56%) had a neoplasm in the pancreatic head, 4 in the body/tail, 2 in the tail and 1 in the body. Histological findings were as follows: Solid pseudopapillary tumor in 10 patients (62.5%), insulinoma in 2 patients, neuroendocrine tumor in 2 patients and acinar cell carcinoma in 2 patients. The most frequent surgery was pancreaticoduodenectomy (50%). Exocrine failure occurred in 4 patients (25%) and endocrine failure in 2 patients (12.5%). Exocrine insufficiency occurred early (within 6 mo after surgery) and endocrine insufficiency later (8 and 10 years after surgery). Mean BMI z-score was 0.36 ± 1.1 at diagnosis and 0.27 ± 0.95 at the last assessment. Vitamin D was insufficient ( 30 ng/mL) in 8 of the 16 patients during the follow-up period. Vitamins A, E and clotting test were into the normal ranges in all patients.

CONCLUSION: Careful and long-term monitoring should follow any pancreatic surgery, to recognize and promptly treat exocrine and endocrine pancreatic insufficiency, which can occur after surgery.

PMID:34616800 | PMC:PMC8464449 | DOI:10.12998/wjcc.v9.i25.7340

BRAF Rearrangements and BRAF V600E Mutations Are Seen in a Subset of Pancreatic Carcinomas With Acinar Differentiation Fetched: October 7th, 2021, 5:00am GMT by Toshi Ghosh

Arch Pathol Lab Med. 2021 Oct 6. doi: 10.5858/arpa.2020-0739-OA. Online ahead of print.

ABSTRACT

CONTEXT.—: Comprehensive genomic profiling has demonstrated that approximately 20% of pancreatic carcinomas with acinar differentiation harbor potentially targetable BRAF fusions that activate the MAPK pathway.

OBJECTIVES.—: To validate the above finding by BRAF break-apart fluorescence in situ hybridization (FISH) in a large series of pure acinar cell carcinomas (ACCs), evaluate tumors for the presence of BRAF V600E mutations, and compare clinicopathologic features of tumors with BRAF rearrangements with those without.

DESIGN.—: Thirty cases of pure ACC and 6 cases of mixed acinar-neuroendocrine carcinoma (ACC-NEC) were retrieved. A break-apart FISH probe was used to detect BRAF rearrangements. Immunohistochemistry for BRAF V600E was performed.

RESULTS.—: BRAF rearrangements by FISH were found in 6 of 36 cases (17%), 5 of which were pure ACC and 1 was a mixed ACC-NEC. Follow-up was available in 29 of 36 (81%). The median survival was 22 months for BRAF-rearranged cases and 16 months for BRAF-intact cases; the 2-year overall survival was 50% for BRAF-rearranged cases and 35% for BRAF-intact cases. No significant clinicopathologic differences were identified in cases with BRAF rearrangement compared with those without BRAF rearrangement. BRAF V600E mutation was identified in 2 of 34 cases (6%), both of which were pure ACC and were BRAF-intact by FISH.

CONCLUSIONS.—: This study supports the finding that BRAF rearrangements are present in approximately 20% of cases and identified BRAF V600E mutations in approximately 5% of cases. These cases may benefit from targeted therapy.

PMID:34614142 | DOI:10.5858/arpa.2020-0739-OA

Pathological complete response in a patient with metastatic pancreatic acinar cell carcinoma who received a chemotherapy regimen containing cisplatin and irinotecan Fetched: October 2nd, 2021, 5:00am GMT by Hiromitsu Maehira

Clin J Gastroenterol. 2021 Oct 1. doi: 10.1007/s12328-021-01518-z. Online ahead of print.

ABSTRACT

Pancreatic acinar cell carcinoma is a rare tumor of the pancreas, and patients with such tumors rarely have a pathological complete response to treatment. Herein, we present a case involving a 48-year-old woman with a pancreatic tail mass. The pancreatic mass was connected to splenic and portal vein thrombosis. Distal pancreatectomy and removal of portal vein tumor thrombosis were performed. Ten months after surgery, multiple liver metastases and local recurrence in the pancreatic bed were detected, and chemotherapy was administered through the administration of a regimen containing both cisplatin and irinotecan. After seven courses of the cisplatin-plus-irinotecan regimen had been administered, computed tomography revealed that the patient had a partial response to treatment. Radical resection of multiple liver metastases and the locally recurrent tumor was performed. Pathological examination did not reveal the presence of carcinoma in any of the resected specimens. Thus, this case involves a pathological complete response in a patient with metastatic pancreatic acinar cell carcinoma who received a regimen containing both cisplatin and irinotecan. Our findings reveal that the administration of the cisplatin-plus-irinotecan regimen may be an option for the management of such tumors.

PMID:34596871 | DOI:10.1007/s12328-021-01518-z

Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis Fetched: September 25th, 2021, 5:00am GMT by Edoardo Del Poggetto

Science. 2021 Sep 17;373(6561):eabj0486. doi: 10.1126/science.abj0486. Epub 2021 Sep 17.

ABSTRACT

[Figure: see text].

PMID:34529467 | DOI:10.1126/science.abj0486

Histologic and Molecular Characterization of Non-Small Cell Lung Carcinoma With Discordant ROS1 Immunohistochemistry and Fluorescence In Situ Hybridization Fetched: September 21st, 2021, 5:00am GMT by Diane M Wilcock

Appl Immunohistochem Mol Morphol. 2021 Sep 16. doi: 10.1097/PAI.0000000000000973. Online ahead of print.

ABSTRACT

INTRODUCTION: ROS1 immunohistochemical (IHC) positivity requires follow-up with confirmatory testing such as fluorescence in situ hybridization (FISH). Identifying predictive characteristics of false positive ROS1 IHC cases could aid in optimizing testing algorithms, decrease testing costs and preserve tissue.

MATERIALS AND METHODS: Retrospective results were retrieved for 2054 patients with non-small cell lung carcinoma submitted to our laboratory for molecular testing. Reflex ROS1 FISH was done on all ROS1 immunoreactive cases using ROS1 D4D6 antibody. Staining intensity and histo-score was recorded for all ROS1 immunoreactive cases. Results of any additional molecular testing (KRAS, BRAF, EGFR, ALK FISH, RET FISH, MET FISH) were also tabulated.

RESULTS: ROS1 immunoreactivity was seen in 305/2054 (14.8%) cases. Immunoreactivity was weak in majority of the cases with only 4.6% cases having an histo-score 100 and 5.9% of cases had moderate staining intensity. FISH was negative in 99% (302/305) cases with any degree of IHC expression (discordant cases) while 3 cases were positive by FISH. Diffuse strong IHC staining in greater than 90% of the tumor was noted in 6 cases, 3 (0.98%) of which were confirmed to have ROS1 rearrangement by FISH. The discordant cases had significantly higher rates of EGFR mutations (P0.0005) in comparison to ROS1 IHC negative cases, were seen more often in adenocarcinoma and adenosquamous cell carcinoma (P0.0005) with lepidic and acinar patterns, and more likely to occur in primary lung carcinomas (P0.0005).

CONCLUSIONS: False positive ROS1 immunoreactivity was very frequent, occurred more commonly in primary NSCLC cases with acinar and/or lepidic histologies and was more likely in EGFR mutated cases. Using higher positivity thresholds for ROS1 IHC and incorporating the histologic and molecular correlates into algorithmic strategies could result in increased specificity and clinical utility of ROS1 IHC assay.

PMID:34534989 | DOI:10.1097/PAI.0000000000000973

Eosinophilic solid and cystic renal cell carcinoma: a clinicopathological analysis of four cases Fetched: September 21st, 2021, 5:00am GMT by X L Li

Zhonghua Zhong Liu Za Zhi. 2021 Sep 23;43(9):955-958. doi: 10.3760/cma.j.cn112152-20191023-00681.

ABSTRACT

Objective: To study the clinicopathological characteristics and prognosis of eosinophilic solid and cystic renal cell carcinoma (ESC RCC). Methods: The clinical pathologic data of 4 cases of ESC RCC diagnosed and treated from 2017 to 2019 at the Second Hospital of Longyan City, the Second Affiliated Hospital of Fujian Medical University, and the Zhangzhou Municipal Hospital were collected. The expression of different antibodies was detected by immunohistochemistry, and the diagnosis and differentiate diagnosis were investigated. Results: The 4 ESC RCC cases included 2 males and 2 females, the average age of these patients was 40 years, ranged from 31 to 51 years. The tumors were composed of solid area mixed with giant vesicles and microcapsules of varying sizes. The cyst cavity was lined by neoplastic cells with voluminous eosinophilic cytoplasm and hobnail arrangement. The solid area appeared as diffuse flaky, dense acinar or nested arrangement, the local area was island-shaped and tubular, mixed with a small amount of histiocytes and lymphocytes. Neoplastic cells contained voluminous eosinophilic cytoplasm with obvious fine or coarse particles, eosinophilic globules in part of the cytoplasm, and intracytoplasmic vacuoles in some areas. Immunohistochemical results showed that tumor cells were CK20 expressed (3/3, 2 cases were sparsely positive and 1 case was patched strongly positive), Vimentin (4/4) and CD10 (4/4) sparsely positive, while Actin, HMB45, Melan-A, CD117 and CK7 were negative in all cases. Ki-67 proliferation index was about 1%. Two cases were followed up and the progression free survival were 18 and 24 months, respectively. Conclusions: ESC RCC has unique histomorphological manifestations, CK20(+ ) and CK7(-) are helpful for its diagnosis, and it has common molecular karyotype changes, supporting it as a unique tumor entity. The overall prognosis of the patient is good.

PMID:34530579 | DOI:10.3760/cma.j.cn112152-20191023-00681

Acinic cell carcinoma of the parotid gland with neuroendocrine differentiation Fetched: September 21st, 2021, 5:00am GMT by Ashutosh Rath

J Cancer Res Ther. 2021 Jul-Sep;17(4):1115-1118. doi: 10.4103/jcrt.JCRT_645_19.

ABSTRACT

Acinic cell carcinoma (ACC) is a malignant salivary gland tumor characterized by tumor cells displaying acinar features. Usually presenting as a slow-growing tumor, ACC, however, may show dedifferentiation to a higher grade including neuroendocrine carcinoma. In addition, ACC may rarely show focal neuroendocrine differentiation without any frank evidence of neuroendocrine carcinoma. We describe such a case of ACC of the parotid gland in a 65-year-old female, which showed neuroendocrine differentiation. The diagnostic clues, immunohistochemistry panel, and prognostic and treatment aspects are also presented.

PMID:34528574 | DOI:10.4103/jcrt.JCRT_645_19

Differential Expression of Peroxisomal Proteins in Distinct Types of Parotid Gland Tumors Fetched: September 21st, 2021, 5:00am GMT by Malin Tordis Meyer

Int J Mol Sci. 2021 Jul 23;22(15):7872. doi: 10.3390/ijms22157872.

ABSTRACT

Salivary gland cancers are rare but aggressive tumors that have poor prognosis and lack effective cure. Of those, parotid tumors constitute the majority. Functioning as metabolic machinery contributing to cellular redox balance, peroxisomes have emerged as crucial players in tumorigenesis. Studies on murine and human cells have examined the role of peroxisomes in carcinogenesis with conflicting results. These studies either examined the consequences of altered peroxisomal proliferators or compared their expression in healthy and neoplastic tissues. None, however, examined such differences exclusively in human parotid tissue or extended comparison to peroxisomal proteins and their associated gene expressions. Therefore, we examined differences in peroxisomal dynamics in parotid tumors of different morphologies. Using immunofluorescence and quantitative PCR, we compared the expression levels of key peroxisomal enzymes and proliferators in healthy and neoplastic parotid tissue samples. Three parotid tumor subtypes were examined: pleomorphic adenoma, mucoepidermoid carcinoma and acinic cell carcinoma. We observed higher expression of peroxisomal matrix proteins in neoplastic samples with exceptional down regulation of certain enzymes; however, the degree of expression varied between tumor subtypes. Our findings confirm previous experimental results on other organ tissues and suggest peroxisomes as possible therapeutic targets or markers in all or certain subtypes of parotid neoplasms.

PMID:34360635 | PMC:PMC8345988 | DOI:10.3390/ijms22157872

Primary pure pancreatic-type acinar cell carcinoma of the stomach Fetched: September 10th, 2021, 5:00am GMT by Shunsuke Uno

Pathol Int. 2021 Sep 9. doi: 10.1111/pin.13164. Online ahead of print.

NO ABSTRACT

PMID:34499781 | DOI:10.1111/pin.13164

Genomic analysis of circulating tumor cells in adenosquamous carcinoma of the prostate: a case report Fetched: September 5th, 2021, 5:00am GMT by Junji Kitamura

BMC Med Genomics. 2021 Sep 3;14(1):217. doi: 10.1186/s12920-021-01068-w.

ABSTRACT

BACKGROUND: Adenosquamous carcinoma of the prostate (ASCP) is an extremely rare and aggressive prostate cancer variant, whose genomic characteristics have not been elucidated. Although liquid biopsy of circulating tumor cells (CTCs) is an emerging topic in oncology, no study has assessed CTCs in patients with ASCP.

CASE PRESENTATION: A 76-year-old man presented with discomfort in his urethra. His prostate-specific antigen (PSA) level was 13.37 ng/mL. A computed tomography (CT) scan indicated a prostate mass with multiple lymph node and lung metastases. The patient underwent transurethral resection of the prostate and prostatic needle biopsy; both specimens demonstrated Gleason grade group 5 acinar adenocarcinoma of the prostate. Bone scintigraphy indicated bone metastasis in the ischium. Combined androgen blockade was implemented, and his serum PSA level rapidly decreased to 0.01 ng/mL. However, a CT scan 6 months after the initial diagnosis revealed worsening of the disease. The patient therefore underwent repeated prostatic needle biopsy; its specimen demonstrated prostatic adenocarcinoma together with squamous carcinoma components. As immunohistochemical analyses showed the tumor cells to be negative for CD56, chromogranin A, synaptophysin, and PSA, the definitive diagnosis was ASCP. Although the patient underwent chemotherapy (docetaxel and cabazitaxel), he died of the disease 3 months after the diagnosis of ASCP, or 13 months after the initial diagnosis of prostatic adenocarcinoma. His PSA values remained ≤ 0.2 ng/mL. CTCs from the patient's blood (collected before starting docetaxel) were analyzed and genomically assessed. It showed 5 cytokeratin (CK)⁺ CTCs, 14 CK^- CTCs, and 8 CTC clusters, per 10 mL. Next-generation sequencing identified a total of 14 mutations in 8 oncogenes or tumor suppressor genes: PIK3CB, APC, CDKN2A, PTEN, BRCA2, RB1, TP53, and CDK12. Of 14 mutations, 9 (64%) were detected on CK^- CTCs and 5 (36%) were detected on CK⁺ CTCs.

CONCLUSIONS: This is the first report of CTC analysis and genomic assessment in ASCP. Although the prognosis of ASCP is dismal due to lack of effective treatment, genomic analysis of CTCs might lead to effective treatment options and improved survival.

PMID:34479548 | PMC:PMC8418023 | DOI:10.1186/s12920-021-01068-w

Bcl-10, trypsin and synaptophysin helps recognize acinar cell and mixed acinar neuroendocrine cell carcinoma of the pancreas on both preoperative cytological samples and needle biopsy specimens Fetched: September 5th, 2021, 5:00am GMT by Erminia Manfrin

Pathol Res Pract. 2021 Oct;226:153593. doi: 10.1016/j.prp.2021.153593. Epub 2021 Aug 24.

ABSTRACT

OBJECTIVE: Acinar cell carcinoma (ACC) of the pancreas are known to be rare and difficult to be recognize because they mimic other unrelated tumors (neuroendocrine, solid pseudopapillary) with different clinical behavior. Especially in the setting of inoperable patients, fine needle aspiration cytology (FNAC), core needle biopsy (FNAB) and immunocyto/histochemistry (ICC/IHC) play a crucial role in the differential diagnosis. The biological material available for ICC tests obtained by minimal invasive procedures is usually limited. Aim of the current study was to evaluate diagnostic panel based on a limited number of ICC markers for typing preoperatively ACC of the pancreas.

METHODS: Of 1820 needle sampling procedures performed and related to pancreatic lesions, 21 cases were extracted with a confirmed diagnosis of ACC on histology. Of them,12 were pure ACC and 9 mixed acinar-neuroendocrine carcinoma (MANEC). Smears of ACC, MANEC and a control group composed of 34neuroendocrine, 7solid pseudopapillary, 50ductal and 4 adenosquamous carcinoma were assessed with an ICC panel made up of BCL10, trypsin, synaptophysin, chromograninA, β-catenin.

RESULTS: On cytology, BCL10 sensitivity and specificity for ACC was 100%. Trypsin correctly recognized 90% of the cases. Synaptophysin was helpful to correctly identify all the cases with a mixed neuroendocrine component. No significant cross-reaction was observed between BCL10 and trypsin in any of the control group case.

CONCLUSIONS: BCL10 is a determinant marker for the diagnosis of acinar cell carcinoma and mixed acinar neuroendocrine cell carcinoma of the pancreas in a pre-operative citologic/histologic setting.

PMID:34481211 | DOI:10.1016/j.prp.2021.153593

Intraductal neoplasms of the pancreas Fetched: September 1st, 2021, 5:00am GMT by Irene Esposito

Pathologe. 2021 Sep;42(5):472-483. doi: 10.1007/s00292-021-00966-1. Epub 2021 Aug 17.

ABSTRACT

The latest WHO classification of tumors of the digestive system (2019) has introduced new concepts for the stratification of intraductal neoplasms of the pancreas, mostly based on molecular genetics and malignant potential. Among them, pancreatic intraepithelial neoplasias (PanINs) and intraductal papillary mucinous neoplasms (IPMN) are both precursors of pancreatic ductal adenocarcinoma, whereas intraductal oncocytic papillary neoplasms (IOPN) and intraductal tubulopapillary neoplasms (ITPN) are usually associated with less aggressive subtypes of pancreatic cancer and therefore have a much better prognosis. Hence, it is of utmost importance to correctly classify these lesions and to distinguish them from each other as well as from other nonductal types of neoplasms, which can rarely display an intraductal growth, such as neuroendocrine tumors and acinar cell carcinomas. PanIN are microscopic lesions with limited clinical significance. In contrast, all other intraductal neoplasms can be identified as cystic processes and/or solid tumors by means of imaging, thereby setting an indication for a potential surgical resection. This review presents diagnostically relevant aspects of intraductal neoplasms of the pancreas, which are instrumental for the discussion within interdisciplinary tumor boards (resection vs. watch-and-wait strategies) as well as to determine the extent of resection intraoperatively.

PMID:34402978 | DOI:10.1007/s00292-021-00966-1

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